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为证实双歧杆菌口服液对人体有无毒性.用Horn法测得口服液LD_(50)为1.0×10~4mg/kg;Ames试验各剂量组加与不加S_9均未诱发回变菌落数增加;微核试验各剂量组与阴性对照组相比差异均无显著性(P>0.05);精子畸变试验畸变率各剂量组与阴性对照组相比差异无显著性(P>0.05);30天喂养试验,体重、肝功、肾功及赃体系数,各剂量组与对照组相比较,差异均无显著性(P>0.05).证明双歧杆菌口服液无效突、致畸及对动物生长发育的不良影响,对人体是安全的.
In order to confirm whether the oral liquid of Bifidobacterium is toxic to the human body, the oral liquid LD_ (50) measured by Horn method is 1.0 × 10 ~ 4mg / kg, Ames test each dose group with or without S_9 (P> 0.05). There was no significant difference in the aberration rate of sperm aberration test between each dose group and the negative control group (P> 0.05) .30 Day feeding test, body weight, liver function, kidney function and stolen body coefficient, there was no significant difference between each dose group and the control group (P> 0.05) .It proved that Bifidobacterium oral solution was ineffective and teratogenic, The adverse effects of growth and development, is safe to the human body.