宫内节育器(IUD)是中国育龄妇女使用最广泛的避孕工具,经量增多、经间点滴出血是IUD的主要不良反应。含吲哚美辛的IUD不仅能发挥良好的避孕效果,而且能避免置器后经量增多、经间点滴出血的不良反应。大量研究表明,吲哚美辛能抑制哺乳动物排卵。因此,研究者对这类含有吲哚美辛IUD的作用机制有了新的认识和探讨空间,即含吲哚美辛的IUD是否有抑制女性排卵、抑制卵子受精的作用。 IUD (IUD) is the most widely used contraceptive for women of childbearing age in China. The meridians increase with volume and intra-venous bleeding is the main adverse reaction of IUD. IUD containing indomethacin not only can exert good contraceptive effect, but also can avoid the adverse reaction caused by the increase of the volume of the device and the bleeding after drip. Numerous studies show that indomethacin can inhibit ovulation in mammals. Therefore, researchers have a new understanding of the mechanism of action of such indomethacin-containing IUDs, and whether the IUD containing indomethacin can inhibit female ovulation and inhibit egg fertilization.