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目的观察注射用血塞通(络泰)对肺心病脏器损伤的保护作用。方法将健康日本大耳兔40只随机分为五组,正常对照组(A组)静脉输入与C、D、E组等量的生理盐水;肺心病模型组(B组)复制肺心病模型后不予处理;注射用血塞通预防组(C组)在复制肺心病模型的同时静脉给予注射用血塞通50mg/kg·d;注射用血塞通治疗组(D组)在复制肺心病模型后静脉给予注射用血塞通50mg/kg·d;西药治疗组(E组)在复制肺心病模型后胃管灌入心痛定2mg/kg·d。观察动物血液中天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、乳酸脱氢酶(LDH)、肌酸磷酸激酶(CK)、尿素氮(BUN)、肌酐(Cr)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、全血粘度(高切和低切)、血浆粘度、红细胞比积、红细胞聚集指数、红细胞变形指数的变化。结果C、D组相关检测项目的改善均优于A、B、E组,且C组多数指标的改善优于D、E组。结论注射用血塞通对肺心病脏器损伤具有保护作用。
Objective To observe the protective effect of Xuesaitong (Lutai) injection on the organ damage of pulmonary heart disease. Methods Forty healthy Japanese rabbits were randomly divided into five groups. The normal control group (group A) received intravenous infusion of saline equivalent to C, D, and E groups; the pulmonary heart disease model group (group B) replicated the model of pulmonary heart disease. No treatment; Injectable Xuesaitong prevention group (C group) was given an injection of Xuesaitong injection 50 mg/kg·d intravenously while replicating the cor pulmonale model; Xuesaitong injection group (D group) was used to replicate pulmonary heart disease. After injection of Xuesaitong 50 mg/kg·d for injection into the model, Western medicine treatment group (E group) was given 2 mg/kg·d of nifedipine into the stomach tube after replicating the pulmonary heart disease model. Observation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine phosphokinase (CK), urea nitrogen (BUN), creatinine (Cr) in animal blood ), interleukin-6 (IL-6), interleukin-8 (IL-8), whole blood viscosity (high and low cut), plasma viscosity, hematocrit, erythrocyte aggregation index, erythrocyte deformability index Variety. Results The improvement of the relevant items in the C and D groups was better than that in the A, B, and E groups. The majority of the C groups improved better than the D and E groups. [Conclusion] Xuesaitong for injection has protective effect on organ damage of pulmonary heart disease.