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目的 :研究羟考酮对左旋氧氟沙星 (L VFX)在人体内药物动力学的影响。方法 :8名健康志愿者 ,单用 L VFX或合用羟考酮 ,用 HPL C法测定血药浓度。结果 :单用 L VFX5 0 0 m g后的药物动力学参数分别为 :tmax(1.5 6 2± 1.0 5 0 ) h,cmax(6 .6 419± 0 .15 86 0 )︼g/ ml,AU C(47.6 5± 11.2 9) h·︼g/ m l,T1 /2 (β) (7.0 34± 0 .941) h;合用羟考酮时 ,L VFX的药物动力学参数分别为 :tmax(1.12 5± 0 .6 41) h,cmax(7.6 5 2± 2 .5 94)︼g/ m l,AU C(48.74± 10 .5 8) h·︼g/ m l,T1 /2 (β) (6 .2 75± 0 .5 88) h。两者除T1 /2 ka和 cmax外 ,无显著性差异。结论 :羟考酮对 L VFX在人体内药物动力学参数无影响。
AIM: To investigate the effects of oxycodone on the pharmacokinetics of levofloxacin (L VFX) in humans. Methods: Eight healthy volunteers were treated with L VFX alone or in combination with oxycodone, and plasma concentrations were determined by HPL C method. Results: The pharmacokinetic parameters of L VFX5 0 0 mg alone were: tmax (1.5 6 2 ± 1.0 5 0) h, cmax (6 .16 ± 0.15 86 0) ︼g / ml, AU C (47.6 ± 11.29) h · ︼g / ml, and T1 / 2 (β) (7.034 ± 0.941) h, respectively. The pharmacokinetic parameters of L VFX with oxycodone were as follows: tmax (1.12 5 ± 0.61 41) h, cmax (7.6 5 2 ± 2 .5 94) ︼g / ml, AU C (48.74 ± 10 .5 8) h · ︼g / ml, T1 / 2 (β) 2 75 ± 0 .5 88) h. There was no significant difference between the two except T1 / 2 ka and cmax. Conclusion: Oxycodone has no effect on pharmacokinetic parameters of L VFX in human.