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目的探讨IL-1基因IL-1B-31/-511位点的多态性与胃癌发病风险I、L-1β分泌水平的关系。方法使用基因芯片检测技术,对胃癌手术患者及消化科十二指肠球部溃疡患者全血标本结合PCR体外扩增方法,检测人IL-1B基因-31和-511位点的基因多态性(IL-1B-31C/T和IL-1B-511C/T)。比较IL-1B基因-31和-511位基因多态性与各种胃癌临床病理参数的关系。结果IL-1B-31及IL-1B-511位点的T携带子在胃癌组与十二指肠球部溃疡患者比较,分别增高胃癌发病风险OR=3.675(95%CI:1.359~9.940)、OR=3.111(95%CI:1.163~8.322)。不论在胃癌组还是在十二指肠球部溃疡组IL-1B-31T携带子-、511 T携带子基因型患者血清IL-1β水平均高于IL-1B-3C/C、-511C/C基因型患者,且IL-1B-31T携带子-、511 T携带子基因型在胃癌组患者的IL-1β水平较十二指肠球部溃疡组患者高。结论IL-1B-31T基因型和IL-1B-511T基因型增加胃癌发病风险,且与IL-1β分泌水平有关。
Objective To investigate the relationship between the polymorphism of IL-1B-31 / -511 locus in IL-1 gene and the risk of gastric cancer I and L-1β secretion. Methods Gene microarray detection was used to detect the gene polymorphisms at the -31 and -511 loci of human IL-1B gene in patients with gastric cancer and whole-blood samples from patients with gastrointestinal tract and duodenal ulcer. (IL-1B-31C / T and IL-1B-511C / T). To compare the association of IL-1B gene -31 and -511 polymorphisms with clinicopathological parameters of various gastric cancers. Results The T carriers in IL-1B-31 and IL-1B-511 loci increased the risk of gastric cancer by OR = 3.675 (95% CI: 1.359-9.940) in patients with gastric cancer and duodenal ulcer, OR = 3.111 (95% CI: 1.163-8.322). The levels of IL-1β in patients with 511 T carrying genotypes were higher than those in IL-1B-3C / C and -511C / C groups, both in gastric cancer group and in duodenal ulcer group Genotype patients, and IL-1B-31T carrying child -, 511 T carrying subgenotype in patients with gastric cancer group IL-1β levels higher than the duodenal ulcer patients. Conclusion IL-1B-31T genotype and IL-1B-511T genotype increase the risk of gastric cancer, and IL-1β secretion level.