目的　探讨溴氰菊酯的心血管毒性及普乐林的保护作用。方法　将豚鼠随机分成溴氰菊酯染毒组、普乐林治疗组以及芝麻油对照组， 应用生理多导记录仪研究其心血管功能的变化。结果　溴氰菊酯染毒后豚鼠血压升高、收缩力加强和心率减慢； 心电图表现为ＱＴｒ 增大、ＱＲＳ 间期延长、ＳＴ 段压低、Ｔ 波加深以及多种心律失常。经普乐林治疗后中毒豚鼠除ＱＴｒ 仍一时性增加外， 其它心血管功能未见明显改变。结论　普乐林对溴氰菊酯中毒豚鼠的心血管毒性具有保护作用。 Objective To investigate the cardiovascular toxicity of deltamethrin and the protective effect of tetralomycin. Methods Guinea pigs were randomly divided into deltamethrin-treated group, pullulan-treated group and sesame oil control group. The changes of cardiovascular function were investigated by using physiological multi-modalities recorder. Results After treatment with deltamethrin, the blood pressure, contractility and heart rate of guinea pigs were increased. The electrocardiogram showed the increase of QTr, the prolongation of QRS interval, the depression of ST segment, the deepening of TT wave and various arrhythmias. Treated guinea pigs after treatment by Putraphine QTr is still a temporary increase in the addition, the other cardiovascular function did not change significantly. Conclusion Pulleline has a protective effect on the toxicity of deltamethrin in guinea pigs.