我们用测定猫冠状窦流量及心肌耗氧量的方法筛选了多种抗心绞痛药物,发现间硝苯吡啶(M-Nif.,天津医工所合成)较硝苯吡啶(Nif.)作用强而持久,毒性则较低,因而系统的对比了二药的药理作用。 一、冠状窦流量及心肌耗氧量:M-Nif20μg/κg iv使猫(n=6)冠状窦流量增加了原水平的92％,峰值时间在3分钟,持续15分钟;同量Nif增加了48％,峰值时间在1分钟,持续10分钟;M-Nif使动静脉氧 We used a variety of anti-anginal drugs to screen the coronary flow and myocardial oxygen consumption in cats. We found that m-Nif. (Synthesized by Tianjin Medical Institute) is stronger than nif. Long-lasting, lower toxicity, and thus a systematic comparison of the pharmacological effects of two drugs. First, the coronary sinus flow and myocardial oxygen consumption: M-Nif20μg / κg iv so that cat (n = 6) coronary sinus flow increased 92% of the original level, the peak time of 3 minutes for 15 minutes; the same amount of Nif increased 48%, the peak time in 1 minute for 10 minutes; M-Nif make arteriovenous oxygen