OBJECTIVE:To investigate the effect of herb-partitioned moxibustion (HPM) on pain and quality of life in women with endometriosis.METHODS:Thirty-six patients will be randomly assigned to a treatment group or a wait-list control group.The treatment group will receive 12 sessions of HPM in the lower abdomen and lumbosacral region for 3 months.Wait-list participants will not receive any specific treatments until the trial is completed.RESULTS:The primary outcome measure is pain intensity assessed by a Visual Analogue Scale at baseline,months 1,2,and 3 in the treatment period,and months 4,5,and 6 in the follow-up period.Secondary outcome measures include quality of life assessed by the Short Form 36 Health Survey,change in CA125,change in cyst diameter (assessed by ultrasound examination),and rescue medication dosage.CONCLUSION:This study will provide evidence to confirm if HPM may be used as a therapeutic option for treating endometriosis.