目的研究ｐ５３及ｂｃｌ２基因在皮脂腺肿瘤中的作用。方法应用免疫组化方法对皮脂腺良、恶性肿瘤上述两种基因产物的表达进行了检测。结果５例皮脂腺癌、２例皮脂腺痣和２例皮脂腺增生症均不同程度表达ｂｃｌ２蛋白，而ｐ５３蛋白仅表达于５例皮脂腺癌的癌细胞。两种蛋白表达强度无相关关系（ｒ’ｓ＝０．１０５，Ｐ＞０．０５）。结论ｐ５３基因突变在皮脂腺癌发生中起决定性作用，而ｂｃｌ２基因则起协同促进作用。检测ｐ５３蛋白可用于鉴别皮脂腺良、恶性肿瘤。 Objective To investigate the role of p53 and bcl2 genes in sebaceous tumors. Methods Immunohistochemistry was used to detect the expression of the above two gene products in benign and malignant sebaceous gland tumors. Results Bcl-2 protein was expressed in 5 cases of sebaceous gland carcinoma, 2 cases of sebaceous glands and 2 cases of sebaceous gland hyperplasia. The p53 protein was only expressed in 5 cases of sebaceous carcinoma cells. There was no correlation between the two protein expression strengths (r’s=0.105, P>0.05). Conclusion The p53 gene mutation plays a decisive role in the occurrence of sebaceous gland carcinoma, while the bcl2 gene plays a synergistic role. Detection of p53 protein can be used to identify benign and malignant sebaceous gland tumors.