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目的研究术后肺腺癌患者组织中TTF-1和SPA的蛋白表达对其复发的预测价值及预后的影响。方法收集行手术切除的Ⅰ~Ⅲ期肺腺癌患者112例,采用免疫组化方法检测组织中TTF-1以及SPA的表达。结果 68例患者出现复发,TTF-1阳性和阴性表达患者中位DFS分别为41个月和9个月(P=0.013),中位OS分别为65.0和23.0个月(P=0.037),SPA阳性与阴性表达患者中位DFS分别为59.0个月和15.0个月(P=0.018),中位OS分别为68.0个月和35.0个月(P=0.058)。结论早期肺腺癌术后组织中TTF-1和SPA的表达是其复发的有效预测指标,TTF-1阳性表达预后更好。
Objective To investigate the effect of protein expression of TTF-1 and SPA on the predictive value and prognosis of patients with recurrent lung adenocarcinoma. Methods One hundred and twelve patients with stage Ⅰ ~ Ⅲ lung adenocarcinoma were collected. Immunohistochemistry was used to detect the expression of TTF-1 and SPA. Results The 68 relapse patients had a median DFS of 41 months and 9 months (P = 0.013), respectively. The median OS was 65.0 and 23.0 months (P = 0.037) The median DFS was 59.0 months and 15.0 months (P = 0.018) for the positive and negative patients, respectively. The median OS was 68.0 months and 35.0 months, respectively (P = 0.058). Conclusion The expression of TTF-1 and SPA in early stage lung adenocarcinoma is an effective predictor of relapse, and the prognosis of TTF-1 positive expression is better.