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人免疫缺陷病毒(human immunodeficiency virus,HIV)是在全球广泛流行并导致严重危害的人类病原体,是由非人灵长类动物免疫缺陷病毒(simian immunodeficiency virus,SIV)跨种传播给人类并进化而来的。本文介绍了SIV跨种传播进化为多种HIV毒株的科学发现及跨种传播病毒在新型宿主中的适应性进化,分析了这些发现的科学和公共卫生意义。
Human immunodeficiency virus (HIV), a human pathogen widely prevalent in the world and causing serious harm, is transmitted to humans by the non-human primate simian immunodeficiency virus (SIV) Come on. This article describes the scientific discovery of the evolution of SIV across multiple species into multiple HIV strains and the adaptive evolution of cross-species viruses in novel hosts. The scientific and public health implications of these findings are analyzed.