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目的:观察复方甘草酸苷对慢性丙型肝炎的疗效。方法:将不能应用干扰素治疗的慢性丙型肝炎60例随机分为观察组和对照组各30例。对照组在基础用药基础上加用甘利欣治疗;观察组在基础用药基础上加用复方甘草酸苷治疗。治疗4周后,比较两组临床症状及体征好转率;两组治疗前后丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST)、血清总胆红素(TBiL)水平变化情况。结果:观察组临床症状及体征有显著好转;两组治疗后ALT、AST、TBiL水平较治疗前显著降低(P<0.05);治疗后,观察组ALT、AST、TBiL水平显著低于对照组(P<0.05)。观察组总有效率86.7%,显著优于对照组73.3%(P<0.05)。结论:复方甘草酸苷对不能应用干扰素治疗的慢性丙型肝炎的疗效优于甘利欣。
Objective: To observe the curative effect of compound glycyrrhizin on chronic hepatitis C Methods: 60 cases of chronic hepatitis C that can not be treated with interferon were randomly divided into observation group and control group, 30 cases each. The control group was treated with Glycyrrhizin on the basis of basic medication; the observation group was treated with compound glycyrrhizin on the basis of the basic medication. After 4 weeks of treatment, the clinical symptoms and the rate of improvement of symptoms were compared. The changes of ALT, AST and TBiL before and after treatment were compared between the two groups. Results: The clinical symptoms and signs of the observation group were significantly improved. The levels of ALT, AST and TBiL in the two groups were significantly lower than those before treatment (P <0.05). After treatment, the levels of ALT, AST and TBiL in the observation group were significantly lower than those in the control group P <0.05). The total effective rate was 86.7% in the observation group, which was significantly better than 73.3% in the control group (P <0.05). Conclusion: Compound glycyrrhizin is superior to glycyrrhizin in treating chronic hepatitis C that can not be treated with interferon.