在西方国家,乳腺癌仍是导致妇女癌症死亡的主要原因,并且发病率仍在上升。乳腺癌在没有明显的远处转移时,局部淋巴结出现转移是预测预后的主要因素,也是早期乳腺癌需要辅助治疗的一个重要指征。本文作者用皮下注射放射性碘单克隆抗体的免疫淋巴闪烁法,作为鉴定淋巴结阳性改变病人的一种新方法。以往类似的研究曾显示,正常淋巴结及其它组织对放射性碘单克隆抗体均有非特异性吸收。作者用添加一种非放射性碘标记抗体的方法,克服了这一问题。用~(131)I In Western countries, breast cancer is still the leading cause of women’s cancer deaths, and the incidence is still rising. In the absence of a significant distant metastasis of breast cancer, the metastasis of local lymph nodes is a major predictor of prognosis, and is an important indicator of the need for adjuvant therapy in early breast cancer. The authors used immunohistopathomic scintigraphy of subcutaneously injected radioiodination monoclonal antibodies as a novel method to identify patients with positive lymph node metastases. Previous studies have shown that normal lymph nodes and other tissues have non-specific absorption of radioactive iodine monoclonal antibodies. The authors overcome this problem by adding a non-radioactive iodine-labeled antibody. With ~(131)I