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目的:探讨胃肠道间质瘤(GIST)临床病理及免疫组化特点。方法:对45例GIST复习其病理形态学,应用CD117、CD34、SMA、S-100等进行免疫组织化学标记。结果:GIST的临床病理特点类似平滑肌肿瘤。免疫组化有其特征性,CD117、CD34呈阳性表达。结论:GIST是消化道最常见的间叶源性肿瘤,临床病理形态类似于平滑肌肿瘤,CD117和CD34阳性表达对诊断有决定性作用。治疗预后不同于平滑肌肿瘤。
Objective: To investigate the clinicopathological and immunohistochemical features of gastrointestinal stromal tumors (GIST). Methods: 45 cases of GIST were reviewed for histopathology. Immunohistochemistry was performed on CD117, CD34, SMA and S-100. Results: The clinicopathological features of GIST resemble those of smooth muscle tumors. Immunohistochemistry has its own characteristics, CD117, CD34 positive expression. Conclusions: GIST is the most common mesenchymal tumor in the digestive tract. The clinical pathology is similar to that of smooth muscle tumors. The positive expression of CD117 and CD34 plays a decisive role in the diagnosis. Treatment prognosis is different from smooth muscle tumors.