树突状细胞(DC)是人体内最强的抗原提呈细胞。未成熟的DC可摄取抗原并迁移至淋巴器官,将抗原信息传递给免疫系统,引发免疫应答。研究表明,DC在启动抗肿瘤免疫中发挥着强大的功能。近年来,以DC为基础的肿瘤疫苗已成为肿瘤免疫治疗的热点。简要综述了各种DC疫苗的制备和临床应用。 Dendritic cells (DCs) are the strongest antigen-presenting cells in the body. Immature DCs can ingest antigens and migrate to lymphoid organs, delivering antigenic information to the immune system, triggering an immune response. Research shows that DC plays a powerful role in initiating anti-tumor immunity. In recent years, the DC-based tumor vaccine has become a hot spot in tumor immunotherapy. The preparation and clinical application of various DC vaccines were briefly reviewed.