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目的探讨C反应蛋白(CRP)、白介素-10(IL-10)、白细胞(WBC)、中性粒细胞比例(N%)在慢性阻塞性肺疾病(COPD)急性加重期诊治中的临床意义。方法采用分析30例患者治疗前及自觉症状好转时血清CRP水平、IL-10、末梢血WBC总数、N%动态变化情况,观察上述指标在急性加重期的阳性率以及自觉症状好转时的阴性率。结果①CRP、IL-10、N%水平在WBC自觉症状好转时均明显低于COPD急性加重期(P均<0.01);②COPD患者急性加重期CRP、IL-10、N%阳性率均高于WBC阳性率,且与后者比较均具有统计学差异(P均<0.01);③COPD患者经治疗自觉症状好转时CRP、WBC阴性率均高于N%阴性率,且与后者比较均具有统计学差异(P均<0.01)。结论血清CRP既可作为COPD患者急性加重期感染的敏感指标,又是反映急性加重期治疗效果的早期评判指标。
Objective To investigate the clinical significance of C-reactive protein (CRP), interleukin-10 (IL-10), white blood cell (WBC) and neutrophil ratio (N%) in the diagnosis and treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD) Methods The changes of serum CRP level, IL-10, the total number of WBC and N% of peripheral blood in 30 patients before and during the improvement of symptoms were analyzed. The positive rate of these indexes in acute exacerbation and the negative rate of negative symptoms were observed . Results ① The levels of CRP, IL-10 and N% in WBC were significantly lower than those in acute exacerbation of COPD (P <0.01) when the symptoms of WBC improved. ② The positive rates of CRP, IL-10 and N% (P <0.01). ③The negative rates of CRP and WBC in patients with COPD improved significantly after the improvement of symptoms, and were statistically significant compared with the latter Difference (all P <0.01). Conclusion Serum CRP can be used as a sensitive indicator of acute exacerbation infection in patients with COPD, but also reflect the early treatment of acute exacerbation of the evaluation criteria.