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目的 为提高甲型肝炎疫苗接种的经济效益和为制订甲肝疫苗免疫策略提供依据。方法 采用成本效益分析、成本效益平衡点分析和抗体水平平衡点分析等卫生经济学评价方法。结果 发现调查地嘉兴市在甲型肝炎发病率为４１．１５／１０ 万的情况下，甲型肝炎疫苗接种的成本效益比为２．５３ ，成本效益平衡点甲型肝炎的发病率应为１６．２６／１０ 万，对甲型肝炎抗体阳性率５０％ 以上的人群接种时，抗体筛选后再接种能节省费用。结论 开展甲型肝炎疫苗的大规模人群接种具有较高的经济效益，１５ ～２９ 岁的人群为接种的首选对象，对２５ 岁以上人群接种前先进行抗体筛选能节省成本。
The purpose is to improve the economic benefits of hepatitis A vaccination and provide evidence for the development of hepatitis A vaccine immunization strategy. Methods Cost-benefit analysis, cost-benefit balance analysis and antibody level equilibrium analysis and other health economics evaluation methods. The results showed that the surveyed Jiaxing City, the incidence of hepatitis A was 41.15 / 100,000, the cost-benefit ratio of hepatitis A vaccination was 2.53, the cost-effective balance of hepatitis A incidence should be 16 .26 / 100000, hepatitis A antibody positive rate of more than 50% of the population vaccination, antibody screening and then vaccination can save costs. Conclusion Large-scale hepatitis A vaccine vaccination is of high economic benefit. The 15- to 29-year-old population is the first choice for vaccination, and antibody screening before 25-year-old population vaccination can save costs.