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对支气管炎患者肌注60mg/12h小诺霉素进行二次和多次给药的药代动力学研究.血清和痰液中2种给药方式的药时曲线是平行的.在治疗第七天,小诺霉素在痰液中浓度明显较高,而在血清中未见积累.这也可由两种AUC值明显不同而得到证实.小诺霉素这种对痰液的良好的渗透能力使其能有效地用于治疗呼吸道感染.选择12名有脓性痰的慢性支气管炎急性发作的住院病人作为研究对象.根据一级一室开放模型,使用输入计算机程序的曲线,由每个患者血清药物浓度来评价药代动力学,即每个患者痰液中小诺霉素浓度也由输入计算机程序曲线计算得到.
Pharmacokinetic studies of second and multiple administrations of intramuscular 60 mg / 12h microtomy in patients with bronchitis The time profiles of the two administrations in serum and sputum are in parallel, Day, the microtomycin concentration was significantly higher in sputum and no accumulation in serum, which is also evidenced by the significant differences between the two AUC values. Tronicase, a good penetration of sputum So that it can be effectively used for the treatment of respiratory infections selected 12 patients with purulent sputum chronic exacerbation of chronic bronchitis as a study object.According to a one-compartment open model, using the input curve of the computer program, by each patient Serum drug concentrations were used to evaluate pharmacokinetics, ie, the concentration of Trichoderma in each patient’s sputum was also calculated from input computer program curves.