为了解被动Heymann肾炎大鼠的氧化、抗氧化状态在蛋白尿形成中作用,分别测定了大鼠血清和尿中维生素E、丙二醛、黄嘌呤氧化酶和24小时尿蛋白。结果显示被动Heymann肾炎大鼠异体相(7天)和自体相(14天)的24小时尿蛋白、血清和尿中MDA、尿VE均明显升高,血VE显著降低,血清和尿XOD始终无明显变化。此外,尿蛋白与血清、尿中MDA、尿中VE呈正相关,与血清VE呈负相关。提示被动Heymann肾炎大鼠存在脂质过氧化反应亢进和抗氧化能力降低。 To understand the role of oxidative and antioxidant status in the formation of proteinuria in passive Heymann nephritis rats, vitamin E, malondialdehyde, xanthine oxidase, and 24-hour urinary protein were measured in rat serum and urine, respectively. The results showed that 24-hour urinary protein, serum and urinary MDA, and urinary VE were all significantly increased in allogeneic (7-day) and autologous (14-day) rats with passive Heymann nephritis, blood VE was significantly reduced, and serum and urine XOD were consistently absent. obvious change. In addition, urinary protein was positively correlated with serum, urinary MDA, urinary VE, and negatively correlated with serum VE. It is suggested that the passive Heymann nephritis rats have lipid peroxidation hyperactivity and reduced antioxidant capacity.