AIM:To review the experience on the use of endoscopicnasopancreatic drainage (ENPD) in the treatment of severeacute pancreatitis (SAP).METHODS:Since March 1998,under the regularmanagement of SAP with non-operative method,ENPD hasbeen randomly used in 14 patients.The average age of thepatients was 41.3±15.9 (years),with 8 males and 6 females.The time from onset to admission was 32.9±22.8 (hours).8cases were found to have gallbladder stone.The daily outputof pancreatic fluid was measured.The body temperature,heart rate,WBC count,blood glucose,blood calcium,PaO_2,blood and urine levels of amylase were detected on the fifthday and compared with their respective data on the first day.Therapeutic results and hospitalization times were recorded.RESULTS:The time of drainage was 7.3±4.0 days.The dailydrainage outputs of the first five days were 236.4±176.6,287.1±164.7,284.6±216.4,435.0±357.8 and 377.8±223.8 ml,respectively.The decreases in body temperature,heart rate,WBC counts,blood and urine levels of amylase and theincrease in PaO_2 were significant on the fifth day whencompared with those on the first day.Infection of pancreaticnecrosis was found in one patient and controlled by anti-infectives.6 out of 8 patients with gallbladder stone wereoperated during hospital stay.All patients were cured anddiischarged and the average hospital stay was 28.1±11.6 days.CONCLUSION:ENPD is an effective method for thedrainage of pancreatic fluid and might have an importantrole in the treatment of SAP.Further observation,comparisonand summary by this method are worthy to be considered. AIM: To review the experience on the use of endoscopic nasopancreatic drainage (ENPD) in the treatment of severe acute pancreatitis (SAP). METHODS: Since March 1998, under the regular management of SAP with non-operative method, ENPD has been randomly selected in 14 patients. The average age of the patients was 41.3 ± 15.9 (years) with 8 males and 6 females. The time from onset to admission was 32.9 ± 22.8 (hours) .8 cases were found to have gallbladder stone. The daily output of pancreatic fluid was measured. The body temperature, heart rate, WBC count, blood glucose, blood calcium, PaO_2, blood and urine levels of amylase were detected on the fifthday and compared with their respective data on the first day. Therapeutic results and hospitalization times were recorded .RESULTS: The time of drainage was 7.3 ± 4.0 days. The dailydrainage outputs the first five days were 236.4 ± 176.6, 287.1 ± 164.7, 284.6 ± 216.4, 435.0 ± 357.8 and 377.8 ± 223.8 ml, respectively. The decrease in body temperature, heart rate , WBC counts, blood an d urine levels of amylase and theincrease in PaO_2 were significant on the fifth day whencompared with those on the first day. Infection of pancreaticnecrosis was found in one patient and controlled by anti-infectives.6 out of 8 patients with gallbladder stone wereoperated during hospital stay . All patients were cured and discharged and the average hospital stay was 28.1 ± 11.6 days. CONCLUSION: ENPD is an effective method for the drainage of pancreatic fluid and might have an importantrole in the treatment of SAP. Future observations, comparison and summary by this method are worthy to be considered.