目的　研究与神经免疫调节有关的功能神经元在大鼠脑内的分布。　方法　以腹腔注射脂多糖(L PS)为免疫激发模型 ,采用免疫组织化学 ABC方法 ,观察 Fos蛋白在脑内的分布情况。　结果　 Fos阳性产物多集中分布在大脑额顶皮质、边缘前脑 (扣带皮质、梨状皮质、外侧隔核和中央杏仁核等 )、丘脑室旁核、下丘脑室旁核、弓状核、视上核、视交叉上核、下丘脑外侧区、中脑导水管周围灰质腹外侧部、外侧臂旁核和延髓内脏带。小脑内无明显 Fos分布密集区。　结论　 L PS诱发的 Fos阳性神经元在脑内有相对广泛的分布 Objective To study the distribution of functional neurons involved in neuroimmunity regulation in rat brain. Methods The intraperitoneal injection of lipopolysaccharide (LPS) was used as the model of immune stimulation. Immunohistochemical ABC method was used to observe the distribution of Fos protein in the brain. Results Fos positive products were mainly distributed in the frontal cortex, the marginal forebrain (cingulate cortex, piriform cortex, lateral septal nucleus and central amygdala, etc.), the paraventricular nucleus of hypothalamus, paraventricular nucleus of hypothalamus, arcuate nucleus, Supraoptic nucleus, suprachiasmatic nucleus, lateral hypothalamic area, midbrain periaqueductal gray, lateral parabrachial nucleus and medullary visceral zone. No obvious Fos distribution in cerebellum. Conclusion LPS-induced Fos-positive neurons have a relatively broad distribution in the brain