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有报道认为,恶性贫血与慢性粒细胞性白血病共存的患者,VB_(12)缺乏对慢粒似乎有调控作用。作者报道一例急性粒细胞性白血病患者,起初表现为典型巨幼贫,经投予大剂量B_(12)(每日1000μg,连用一周)后,迅速转为急性粒细胞性白血病。后又经体外细胞培养(即加B_(12)于患者的骨髓原始细胞培养中),证实这种细胞集落的形成能力明显增加。因此,作者认为,B_(12)缺乏对急粒白血病食调抑作用。同时认为,B_(12)缺乏患者造血系恶性疾病的发病率增加,某些病例若大剂量补充B_(12),可加速这种恶性疾病的发
It has been reported that, in patients with pernicious anemia and chronic myeloid leukemia coexistence, VB_ (12) deficiency seems to have a regulatory role in chronic particles. The authors report that a patient with acute myeloid leukemia, initially presenting as a typical megaloblastic poor, was rapidly converted to acute myeloid leukemia after administration of a large dose of B 12 (1000 μg daily for one week). After in vitro cell culture (ie B_ (12) in the patient’s bone marrow blasts), the ability of this cell colony to form was significantly increased. Therefore, the author believes that B_ (12) lack of acute myeloid leukemia inhibitory effect. In the meantime, the incidence of malignant diseases in hematopoietic malignancies is increased in patients with B_ (12) deficiency. In some cases, if large doses of B_ (12) are added, the incidence of this malignant disease may be accelerated