Objectives: To evaluate the efficacy and safety of mechanical debridement and suturing of the laser in situ keratomileusis (LASIK) flap in the treatment of cl inically significant epithelial ingrowth after LASIK. Methods: In a retrospectiv e study, 20 eyes (n=19 patients) in which clinically significant epithelial ingr owth developed after LASIK were treated with lifting of the flap, scraping of th e epithelial ingrowth, and flap suturing. Primary outcome measurements including recurrence of ingrowth, uncorrected visual acuity (VA), manifest refraction, be st spectacle-corrected VA, and complications were evaluated at the last postope rative examination. Results: At the last postoperative examination (mean±SD, 10 .5 ±14.3 months; range, 1.5-64 months), 100%of eyes had no recurrence of clin ically significant epithelial ingrowth. The uncorrected VA changed from 20/20 or better in 7 eyes (35%) and 20/40 or better in 15 eyes (75%) preoperatively to 20/20 or better in 9 eyes (45%) and 20/40 or better in 16 eyes (80%) at the l ast follow-up examination. There was no significant change in the mean logarith m of the minimum angle of resolution (logMAR) uncorrected VA before (mean±SD, 0 .3±0.5; range, -0.1 to 1.7) and after surgery (mean±SD, 0.2±0.4; range, -0. 1 to 1.7) (P=.40). Mean±SD spherical equivalent changed from -0.21±0.82 diopt ers (D) (range, -1.25 to 1.00 D) preoperatively to -0.53±0.89D (range, -2.50 to 0.38 D) at last follow-up (P=.30). No eyes lost 2 or more lines of best spe ctacle-corrected VA, and there were no complications as sociated with the treatment. Conclusions: Suturing the LASIK flap in addition to mechanical debridement of epithelial ingrowth is a safe and effective treatme nt for clinically significant epithelial ingrowth after LASIK. Objectives: To evaluate the efficacy and safety of mechanical debridement and suturing of laser in situ keratomileusis (LASIK) flap in the treatment of cl inically significant epithelial ingrowth after LASIK. Methods: In a retrospectiv e study, 20 eyes (n = 19 patients ) in which clinically significant epithelial ingr owth developed after LASIK were treated with lifting of the flap, scraping of th e epithelial ingrowth, and flap suturing. Primary outcome measurements including recurrence of ingrowth, uncorrected visual acuity (VA), manifest refraction, be st spectacle-corrected VA, and complications were evaluated at the last postoperation examination. Results: At the last postoperative examination (mean ± SD, 10 .5 ± 14.3 months; range, 1.5-64 months), 100% of eyes had no recurrence of uncorrected VA changed from 20/20 or better in 7 eyes (35%) and 20/40 or better in 15 eyes (75%) preoperatively to 20/20 or better in 9 eyes (45% ) and 20 / 40 or better in 16 eyes (80%) at the l ast follow-up examination. There was no significant change in the mean logarithm of the minimum angle of resolution (logMAR) uncorrected VA before (mean ± SD, 0.3 Range -0.1 to 1.7) and after surgery (mean ± SD, 0.2 ± 0.4; range, -0.1 to 1.7) (P = .40). Mean ± SD spherical equivalent changed from -0.21 ± 0.82 diopt ers (D) (range, -1.25 to 1.00 D) preoperatively to -0.53 ± 0.89D (range, -2.50 to 0.38 D) at last follow-up (P = .30). No eyes lost 2 or more lines of best spe ctacle-corrected VA, and there were no complications as sociated with the treatment. Conclusions: Suturing the LASIK flap in addition to mechanical debridement of epithelial ingrowth is a safe and effective treatme nt for clinically significant epithelial ingrowth after LASIK.