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由于腹腔镜手术比常规手术术后疼痛轻、住院时间短和正常活动恢复早。因此已用于结直肠癌手术。不过这种手术对恶性病变的作用存有争议。作者为评估腹腔镜手术和常规手术术后肿瘤生长的差异,对鼠进行了实验研究。 实验分两部分:①于雄性大鼠腹膜内注入5×10~5CC-531结肠癌细胞,2天后将鼠随机分成3组。1组(n=13)动物接受剖腹小肠切除,2组(n=13)动物行腹腔镜小肠切除,3组(n=8)动物单纯麻醉。注射瘤细胞后4周处死动物检验肿瘤生长情况。②于鼠双侧肾被膜下植入重约8mg的CC-531实体结肠肿瘤片,5天后8只鼠接受剖腹小肠切除,8只腹腔镜小肠切除,6只单纯麻
Because laparoscopic surgery is less painful than usual, shorter hospital stay and early recovery of normal activities. It has therefore been used in colorectal cancer surgery. However, this kind of surgery has controversial effects on malignant lesions. To assess the differences in tumor growth after laparoscopic surgery and conventional surgery, the rats were studied experimentally. The experiment was divided into two parts: 1 Male rats were injected intraperitoneally with 5×10~5CC-531 colon cancer cells. Two days later, the rats were randomly divided into three groups. One group (n=13) of animals underwent laparoscopic small bowel resection, two groups (n=13) of animals underwent laparoscopic small bowel resection, and three groups (n=8) of animals underwent anesthesia alone. Tumor cells were sacrificed 4 weeks after the injection of tumor cells to examine tumor growth. 2CC-531 solid colon tumors weighing approximately 8 mg were implanted under bilateral renal capsules in rats. After 5 days, 8 rats underwent laparotomy, 8 laparoscopic small bowel resections and 6 plain hemps.