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目的观察甲状腺功能亢进症(甲亢)应用小剂量他巴唑治疗的安全性与有效性。方法 40例甲状腺功能亢进症患者,将其按照随机抽取的方式分为观察组与对照组,每组20例。观察组给予小剂量他巴唑治疗,对照组给予大剂量他巴唑治疗。观察两组患者的临床总有效率、不良反应发生率、临床症状评分。结果观察组临床总有效率为95.00%,对照组临床总有效率为90.00%,两组临床总有效率比较差异无统计学意义(P>0.05)。观察组不良反应发生率为5.00%,低于对照组的30.00%,差异具有统计学意义(P<0.05)。观察组患者的临床症状评分均明显低于对照组,差异均具有统计学意义(P<0.05)。结论他巴唑治疗甲状腺功能亢进症效果显著,但小剂量治疗安全性比较高,治疗效果确切,值得推广及应用。
Objective To observe the safety and efficacy of the low dose methpazole treatment for hyperthyroidism (hyperthyroidism). Methods Forty patients with hyperthyroidism were randomly divided into observation group and control group, with 20 cases in each group. The observation group was treated with low dose methbazole, and the control group was treated with large dose of methimazole. The total effective rate of the two groups of patients, the incidence of adverse reactions, clinical symptoms score. Results The total clinical effective rate was 95.00% in the observation group and 90.00% in the control group. There was no significant difference in the total effective rate between the two groups (P> 0.05). The incidence of adverse reactions in the observation group was 5.00%, which was lower than that in the control group (30.00%), the difference was statistically significant (P <0.05). Clinical symptom score in observation group was significantly lower than that in control group, the differences were statistically significant (P <0.05). Conclusion Metarizole treatment of hyperthyroidism effect is significant, but low-dose treatment of high safety, the exact effect of treatment, it is worth promoting and application.