论文部分内容阅读
目的比较经直肠与经会阴穿刺125Ⅰ粒子植入放疗治疗局限性前列腺癌的疗效。方法对42例局限性前列腺癌患者行125Ⅰ粒子植入放疗,其中20例经直肠穿刺(经直肠组),22例经会阴穿刺(经会阴组)。粒子植入后监测两组前列腺特异性抗原(PSA)水平变化,每个月随访1次,PSA连续检测3次不复升后改为每3个月随访1次。每半年评估1次尿路及直肠并发症发生情况。结果与经会阴组比较,经直肠组穿刺针数少、植入操作时间及植入后住院时间短(P均<0.05)。随访25~46个月,两组生化控制率、2年生化无复发率及尿路、直肠并发症发生率均无统计学差异。结论经直肠及经会阴穿刺125Ⅰ粒子植入放疗治疗局限性前列腺癌的疗效相当,但经直肠穿刺操作更方便,且创伤小。
Objective To compare the curative effect of transrectal and perineal puncture with 125 Ⅰ particle implantation radiotherapy in the treatment of localized prostate cancer. Methods Forty-two patients with localized prostate cancer underwent radiotherapy with 125 I seeds. Of these, 20 received transrectal rectal (rectal) and 22 received perineal (transperineal) puncture. After the implantation, the levels of prostate-specific antigen (PSA) in the two groups were monitored and followed up once a month. The patients were followed up once every three months for three times without PSA. Urinary tract and rectal complications were assessed semi-annually. Results Compared with the perineal group, the number of puncture needles in the rectal group was shorter, the operation time and length of stay after implantation were shorter (all P <0.05). Follow-up 25 to 46 months, two groups of biochemical control rate, 2-year rate of non-recurrence of biochemistry and urinary tract, rectal complications were no significant difference. Conclusion Rectal and perineal puncture 125I particles implantation radiotherapy for the treatment of localized prostate cancer is quite effective, but the rectal puncture is more convenient and less invasive.