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按照粘液组化染色结果，９６例人类胃粘膜上皮异型增生标本，被区分为分泌中性粘液的异型增生（ＮＭ－ｄｙｓ）５７例和分泌非中性粘液的异型增生（Ｎ－ＮＭ－ｄｙｓ）３９例两类。中、重度异型增生的检出率，在ＮＭ－ｄｙｓ中为３６．８％（２１／５７），在Ｎ－ＮＭ－ｄｙｓ中为７６．９％（３０／３９），两者比较差异有显著性（Ｐ＜０．０５）；免疫组化染色结果显示，Ｐ２１、Ｐ５３蛋白表达阳性率在Ｎ－ＮＭ－ｄｙｓ中（５３．３％、４８．７％）亦显著地高于ＮＭ－ｄｙｓ（２４．６％、２２．８％）（Ｐ＜０．０５）。结果表明：分泌非中性粘液的异型增生组织细胞基因表达异常，细胞分化功能障碍，带有更多与胃癌相同的生物学性状，应视为重要的胃癌前病变。我们建议将粘液组化染色列为判断胃粘膜上皮异型增生是否容易恶变的一个初筛指标。
According to the result of mucin staining, 96 cases of gastric mucosal epithelial dysplasia were divided into 57 cases of NM-dysplasia and N-NM-dysplasia of non-neutral mucus, 39 cases of two types. The detection rate of moderate and severe dysplasia was 36.8% (21/57) in NM-dys and 76.9% (30/39) in N-NM-dys, with significant difference between the two (P <0.05). Immunohistochemical staining showed that the positive rates of P21 and P53 protein in N-NM-dys (53.3%, 48.7%) were also significantly higher than those in NM-dys 24.6%, 22.8%) (P <0.05). The results showed that the dysplasia of dysplasia and dysplasia of dysplasia of dysplastic tissue secreting non-mucinous mucus with more biological characteristics as gastric cancer should be regarded as important precancerous lesions of stomach. We suggest that the mucoid staining as a judge of gastric epithelial dysplasia is easy to malignant transformation of a screening index.