当前已有四千余种化合物被推荐为药用,其中95%以上是在1930年以后完成的。但寻找新药的成功率仍然很低,在每2000～5000个被试物质中,最后仅有一种可能被临床选用。因此,如何更合理地进行药物设计, More than 4,000 compounds are currently recommended for medicinal purposes, of which more than 95% are completed after 1930. However, the success rate of finding new drugs is still very low. Only one of the 2000-5000 test substances may be clinically used. Therefore, how to conduct more rational drug design,