例1 男患32岁。因头晕、乏力50天,于1987年9月11日入院。无糖尿病既往史和家族史。体检T37℃,BP16/10kPa,贫血貌,浅表淋巴结未触及。胸骨压痛(+)。心肺(-)。肝脾肋下未触及。Hb63g/L,WBC12.4×10~9/L,N0.43,L0.26,幼稚细胞0.31。骨髓增生极度活跃,原粒91%,早幼粒1%,可见 Auer 小体。空腹血糖5.38mmol/L,餐后2小时血糖6.4mmol/L。尿糖(-)。诊断为急性粒细胞白血病(M_1)。给以 HOAP 方案(三尖杉酯碱,长春新碱、强地松、阿糖胞苷)化疗,7天1疗程。3个疗程后病情明显好转,复查骨髓原粒28%,以后间断用小剂量阿糖胞苷化疗。11月9日出现恶心呕吐,对症处理病情无好转。11月11日出现口渴、多饮、多尿、逐渐进入昏迷。眼底检查无异常。脑脊液 Example 1 male suffering from 32-year-old. Due to dizziness, fatigue 50 days, on September 11, 1987 admission. No history of diabetes and family history. Physical examination T37 ℃, BP16 / 10kPa, anemia appearance, superficial lymph nodes not touched. Sternal tenderness (+). Cardiopulmonary (-). Liver and spleen ribs untouched. Hb63g / L, WBC12.4 × 10 ~ 9 / L, N0.43, L0.26, naive cells 0.31. Myeloid hyperplasia is extremely active, the original particle 91%, promyelocytic 1%, visible Auer body. Fasting blood glucose 5.38mmol / L, 2 hours postprandial blood glucose 6.4mmol / L. Urine (-). Diagnosis of acute myeloid leukemia (M_1). To HOAP program (harringtonine, vincristine, prednisone, cytarabine) chemotherapy, 7 days a course of treatment. After 3 courses, the condition was obviously improved. The original bone marrow of 28% was examined. After that, it was interrupted with low dose of cytarabine chemotherapy. November 9 nausea and vomiting, symptomatic treatment of the disease did not improve. November 11 appear thirsty, drink more, more urine, and gradually into a coma. Fundus examination without exception. Cerebrospinal fluid