恶性胸膜间皮瘤(MPM)的常规治疗效果不好,存在免疫抑制作用。用肿瘤浸润性淋巴细胞(TIL)抗肿瘤,是近年来过继免疫治疗的一个新途径。我们用TIL、白细胞介素2(IL-2)、干扰素(IFN)协同治疗3例MPM,初步观察效果较好。 3例病人中男2例,女1例,年龄50～68岁,均经病理学证实为MPM,其中1例伴腹膜间皮瘤。无菌抗凝采集胸水,常规分离得到淋巴细胞,将细胞调至1～2×10~6/ml,置含8％人AB血清的RPMI1640中,加IL-2诱导7～20天,洗涤细胞备 The conventional treatment of malignant pleural mesothelioma (MPM) is not effective and has immunosuppressive effects. The use of tumor-infiltrating lymphocytes (TIL) to fight cancer is a new approach to adoptive immunotherapy in recent years. We used TIL, interleukin-2 (IL-2) and interferon (IFN) to treat 3 cases of MPM. In 3 patients, there were 2 males and 1 female, aged 50-68 years. All of them were confirmed by pathology as MPM, and 1 was associated with peritoneal mesothelioma. Sterile anticoagulant collection of pleural effusion, routine isolation of lymphocytes, the cells were adjusted to 1 ~ 2 × 10 ~ 6/ml, set in RPMI1640 containing 8% of AB serum, plus IL-2 induced 7 ~ 20 days, washed cells Prepare