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目的探讨脑淀粉瘤的临床病理特征、免疫表型及其鉴别诊断。方法应用常规病理及免疫组化和组织化学观察1例脑淀粉瘤,并复习相关文献。结果组织学上,肿瘤主要由粉红色无结构如带壳栗子状的沉着组成,病灶周围有淋巴细胞浸润,未见胶质成分;边缘神经细胞排列松散,有粉红的无结构沉着物质,毛细血管增生不明显,血管壁未见淀粉样改变,脑水肿不明显。免疫组化示肿瘤细胞嗜刚果红染色。病灶周围T淋巴细胞CD3和GFAP(+)。结论脑淀粉瘤是一种少见的特殊类型脑内良性肿瘤,肿瘤发生原因复杂,嗜刚果红染色是有效的诊断方法。
Objective To investigate the clinicopathological features, immunophenotype and differential diagnosis of cerebral amyloidosis. Methods One case of cerebral amyloidosis was observed by routine pathology, immunohistochemistry and histochemistry. The related literatures were reviewed. Results Histologically, the tumors mainly consisted of pink, unstructured, chestnuts-like sellae with infiltration of lymphocytes around the lesion and no glial components. The marginal nerve cells were arranged in a loose, pink, unstructured, capillary Hyperplasia is not obvious, no changes in amyloid wall, cerebral edema is not obvious. Immunohistochemistry showed that the tumor cells were congophilic red staining. T lymphocytes around the lesion CD3 and GFAP (+). Conclusions Cerebral amyloidosis is a rare and special type of brain benign tumor. The cause of the tumor is complex, and the detection of ecdysterin is an effective diagnostic method.