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目的探讨实验性脊髓空洞症致脊柱侧弯发病机制。方法24只中国白兔,其中12只制作脊髓空洞模型,另12只作对照。定期MR扫描,拍脊柱正侧位片判断侧弯程度,并用光镜观察脊髓和椎旁肌肉标本。结果4~6周时,9只动物中8只出现脊髓空洞,6只出现颈胸段脊柱侧弯;8周以后,空洞随观察时间延长而逐渐增大、受累节段增多,同时脊柱侧弯程度也明显加重。椎旁肌肉出现代表神经源性变性的小角纤维。结论实验性脊髓空洞症常引起脊柱侧弯,脊柱侧弯加速脊髓空洞发展,及早终止两者的恶性循环将有助于改善本病的预后。
Objective To investigate the pathogenesis of scoliosis induced by experimental syringomyelia. Methods Twenty-four Chinese white rabbits, including 12 rabbits, were made into syringomyelia and the other 12 rabbits were used as controls. Regular MR scan, the spine is a lateral film to determine the degree of scoliosis, and the use of light microscopy spinal cord and paravertebral muscle specimens. Results At 4 to 6 weeks, 8 of the 9 animals showed cavitary syringomyelia and 6 of them showed scoliosis of the neck and neck. After 8 weeks, the cavity increased gradually with the prolongation of observation time, and the involved segments increased. At the same time, the scoliosis Degree also significantly increased. Paravertebral muscles appear small angle fibers representing neurogenic degeneration. Conclusions Experimental syringomyelia often leads to scoliosis. Scoliosis accelerates the development of syringomyelia and early termination of the vicious circle will help to improve the prognosis of the disease.