目的　探讨慢性肝病患者血清白蛋白 ,α1 、α2 和 β球蛋白 (非γ球蛋白 )与γ球蛋白比值的临床应用。方法　采用血清蛋白电泳方法 ,分离出 3 0 0例样品的白蛋白 ,α1 、α2 、β和γ球蛋白 ,计算出非γ球蛋白与γ球蛋白比值 ,并同血清白蛋白与球蛋白比值 (A G)进行比较。结果　两种比值间有非常显著性差异 (P <0 .0 1) ,在 2 0 2例A G正常样品中 ,有 5 3 .5 %的样品非γ球蛋白与γ球蛋白比值降低 ,显示其灵敏度大于高于A G。结论　非γ球蛋白与γ球蛋白比值比A G更能反映慢性肝病肝损害程度 ,具有重要的临床意义 Objective To investigate the clinical application of serum albumin, α1, α2 and β globulin (γ-globin) ratio in patients with chronic liver disease. Methods The albumin, α1, α2, β and γ globulin of 300 samples were isolated by serum protein electrophoresis and the ratio of non-gamma globulin to gamma globulin was calculated and compared with the ratio of serum albumin to globulin AG) for comparison. Results There was a significant difference between the two ratios (P <0.01). In 202 samples of normal AG, 53.5% of samples showed a decrease in the ratio of non-gamma globulin to gamma globulin Sensitivity greater than AG. Conclusion The ratio of non-γ-globulin to γ-globulin is better than A G in reflecting the degree of liver damage in patients with chronic liver disease and has important clinical significance