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鼠疫是一种古老的烈性传染病,历史上有记载的大流行就有3次,这个俗称“黑死病”的瘟疫曾使欧洲的人口减少了四分之一,并改变了历史进程。20世纪以来,印度、越南、非洲等地均出现过鼠疫的大流行,而近年来鼠疫流行主要集中在非洲撒哈拉地区、东非、马达加斯加等地。随着恐怖主义者利用鼠疫耶尔森菌气雾剂作为生物武器,鼠疫重新引起全世界的关注。由于传统治疗鼠疫的药物如链霉素、氯霉素、四环素在许多国家已经停产或停用,因此需要找到新的合适的治疗药物。为了验证庆大霉素治疗鼠疫的有效性和安全性,并为治疗生物恐怖导致的鼠疫提供经验,2002年在坦桑
The plague was an ancient, highly contagious disease. There were three recorded epidemics in history. The plague, commonly known as “the Black Death,” had eased the population of Europe by a quarter and changed the course of history. Since the 20th century, there has been a plague of plague in India, Vietnam and Africa. In recent years, the epidemic has been mainly concentrated in sub-Saharan Africa, East Africa and Madagascar. With the use of Yersinia pest aerosols as a biological weapon by terrorists, the plague has rekindled worldwide attention. As traditional treatments for plague drugs such as streptomycin, chloramphenicol and tetracycline have been discontinued or discontinued in many countries, new suitable therapeutic drugs need to be found. In order to verify the effectiveness and safety of gentamicin in the treatment of plague and to provide experience in the treatment of plague caused by bioterrorism,