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目的系统评价p53在三阴性乳腺癌中的表达情况以及其阳性表达对三阴性乳腺癌患者的预后因素的影响。方法通过PubMed、Medline、CNKI、WanFang data、VIP数据库检索国内外已公开发表的相关文献资料。由2位研究者按照纳入与排除标准独立筛选文献、提取资料和质量评价后,采用RevMan 5.0软件进行Meta分析。结果纳入文献13篇,其中中文文献11篇,英文文献2篇。Meta分析结果显示:p53蛋白在三阴性乳腺癌患者中的表达较高,具有显著的统计学意义[OR=2.02,95%CI(1.28,3.19)]。三阴性乳腺癌中p53阳性表达组的淋巴结转移率和复发率高于阴性组,无病生存率和总生存率低于阴性组,且结果均有统计学意义。结论 p53在三阴性乳腺癌中高表达,且具有一定的临床预后指导意义,其可以作为评估三阴性乳腺癌预后的一个独立因素,且在以后的研究中,有可能可作为指导三阴性乳腺癌靶向治疗的一个靶点。
Objective To evaluate the expression of p53 in triple negative breast cancer and its effect on the prognosis of patients with triple negative breast cancer. Methods PubMed, Medline, CNKI, WanFang data and VIP database were used to search the related documents published at home and abroad. Two researchers independently screened the literature according to the inclusion and exclusion criteria, extracted data and quality evaluation, and used RevMan 5.0 software to conduct meta-analysis. The results included 13 articles, including 11 Chinese and 2 English articles. The results of Meta analysis showed that the expression of p53 protein was higher in triple-negative breast cancer patients, with significant statistical significance (OR = 2.02, 95% CI 1.28,3.19). The positive rates of lymph node metastasis and recurrence of p53 positive expression group in triple negative breast cancer were higher than those in negative group, and the disease free survival rate and overall survival rate were lower than those in negative group. The results were statistically significant. Conclusion The high expression of p53 in triple-negative breast cancer has certain clinical prognostic significance, which can be used as an independent factor to evaluate the prognosis of triple-negative breast cancer. In the later study, it may be used as a guide for triple-negative breast cancer A target for treatment.