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目的检测妊娠期高血压疾病患者随机尿蛋白与血浆肌酐比值的变化,分析其在评估妊娠期高血压疾病病情严重程度中的作用。方法选择轻度子痫前期孕妇99例,重度子痫前期孕妇90例作为实验组,选择正常孕晚期孕妇100例作为对照组。检测随机尿蛋白、24h尿蛋白及血浆肌酐水平进行统计分析。结果轻度子痫前期、重度子痫前期组随机尿蛋白与血浆肌酐比值较正常孕晚期组增高,差异有统计学意义(P<0.05),且随病情加重,随机尿蛋白与血浆肌酐比值差异明显增加,轻度子痫前期与重度子痫前期组比较,差异有统计学意义(P<0.01)。结论随机尿白蛋白/肌酐比值与子痫前期病情严重程度存在高度相关性,能够替代24h尿蛋白定量,更为快捷、简便地评估子痫前期病情严重程度。
Objective To detect the changes of the ratio of random urine protein to plasma creatinine in patients with hypertensive disorder complicating pregnancy and to analyze its role in the evaluation of the severity of hypertensive disorder complicating pregnancy. Methods Ninety-nine pregnant women with mild preeclampsia and 90 pregnant women with severe preeclampsia were selected as experimental group. One hundred pregnant women of normal pregnancy were selected as the control group. Random urine protein, 24h urine protein and plasma creatinine levels were statistically analyzed. Results In mild preeclampsia and severe preeclampsia, the ratio of random urine protein to plasma creatinine was higher than that in normal third trimester (P <0.05), and with the increasing of disease, the ratio of random urine protein to plasma creatinine was significantly lower Significantly increased, mild preeclampsia and severe preeclampsia group, the difference was statistically significant (P <0.01). Conclusions There is a high correlation between the ratio of random urine albumin / creatinine and the severity of preeclampsia, which can replace the quantitation of urinary protein in 24 hours. It is quick and easy to evaluate the severity of preeclampsia.