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目的探讨儿科迁延性和慢性腹泻病 (PCDD)病原体及主要致病菌对常用抗生素敏感性的变迁。方法对近 10年来 PCDD与急性腹泻病 (ADD)各种病原体检出率进行比较。对 PCDD常见病原体检出率及抗生素敏感率进行逐年统计 ,并进行前后 5年比较。结果PCDD组白色念珠菌、变形杆菌属、枸椽酸杆菌、铜绿假单胞菌、沙雷杆菌、金黄色葡萄球菌、耶尔森菌、新型隐球菌、难辨梭状芽胞杆菌及肠道毛滴虫、溶组织阿米巴原虫、隐孢子虫等检出率较高。而 ADD组轮状病毒、肠毒性大肠杆菌、志贺氏菌属检出率较高。PCDD组条件致病菌检出率逐渐增高 ,而原虫检出率则逐渐降低 ,细菌对常用抗生素敏感率逐渐降低 ;前后 5年比较白色念珠菌、变形杆菌属、枸椽酸杆菌属、肠道毛滴虫检出率有显著性差异 (P<0 .0 5 ) ,溶组织阿米巴原虫检出率有非常显著性差异 (P<0 .0 1) ,青霉素、氨苄青霉素、头孢唑啉、氯霉素、庆大霉素敏感率有显著性差异 (P<0 .0 5 ) ,而头孢三嗪、丁胺卡那霉素、氟哌酸、环丙沙星敏感率无显著性差异 (P>0 .0 5 )。结论 PCDD近 10年来条件致病菌感染逐渐增多 ,而原虫感染则逐渐降低。细菌对常用抗生素敏感率逐渐降低 ,但对头孢三嗪、丁胺卡那霉素、氟哌酸、环丙沙星敏感率下降不明显
Objective To investigate the changes of susceptibility to common antibiotics in pediatric protracted and chronic diarrhea (PCDD) pathogens and major pathogenic bacteria. Methods The detection rates of various pathogens in PCDD and acute diarrhea (ADD) in the recent 10 years were compared. The detection rate of PCDD common pathogens and antibiotic susceptibility rates were statistically analyzed annually, and compared before and after 5 years. Results PCDD group Candida albicans, Proteus, Citric acid bacteria, Pseudomonas aeruginosa, Serratia, Staphylococcus aureus, Yersinia, Cryptococcus neoformans, Clostridium difficile and intestinal hair Trichomonas, Entamoeba histolytica, Cryptosporidium detection rate is higher. The ADD group of rotavirus, enterotoxigenic Escherichia coli, Shigella detection rate is higher. The detection rate of pathogenic bacteria increased gradually in PCDD group, but the detection rate of protozoa decreased gradually. The sensitivity rate of bacteria to commonly used antibiotics decreased gradually. The frequency of Candida albicans, Proteus, Citrobacter, gut The detection rate of Trichomonas vaginalis was significantly different (P <0.05), the detection rate of Entamoeba histolytica was significantly different (P <0.01), penicillin, ampicillin, cefazolin , Chloramphenicol and gentamicin (P <0.05), while the sensitivity of cefotaxime, amikacin, norfloxacin and ciprofloxacin showed no significant difference (P> 0.05). Conclusion PCDD infection gradually increased in the past 10 years, while protozoal infection decreased gradually. The susceptibility of bacteria to commonly used antibiotics decreased gradually, but the sensitivity to cefotaxime, amikacin, norfloxacin and ciprofloxacin did not decrease significantly