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目的观察奥美拉唑与氧氟沙星合用对消化性溃疡的临床疗效及对幽门螺旋杆菌（HP）感染的清除率。方法消化性溃疡患者50例，均经胃镜检查及尿素酶法测定证实HP阳性。给予奥美拉唑20mg，p.o，bid，和氧氟沙星200mg， p.o，bid，疗程两周。结果溃疡愈合率、HP根除率和无效率分别为64%、88%、12%。结论奥美拉唑与氧氟沙星合用能明显缓解消化性溃疡症状，是安全有效的HP根除方案，14日疗程可能获得较好的疗效，副作用小。“,” Objective To observe the clinical effects of ompragole in combination with ofloxacin on peptic ulcer and the rate of eliminating helicobacter pylori infections. Methods The fifoty patients with Peptic ulcer proven by endoscopy and positive clo-test. Received omepragole 20 mg p.o, bid, plus ofloxacin 200 mg, p.o, bid. The course of treatment were 2wk for both agents. Results the ulcer healing rate, HP elinminating rate and ineffective rate were 64%, 88%and 12%respectively. Conclusion Using omepragole combined with ofloxacin can obviously relieve the symptom of peptic ulcer are safe and effective programs for helicobacter pylori eradication, the 14days therapy can get a good effect on treatment,and with few adverse reactions.