本实验使用形态学方法在切片上计算细胞数以比较N-甲酰溶肉瘤素对小鼠各种器官所引起病变的发展过程,并从数量上去衡量各种细胞对药物的敏感性。结果发现小鼠腹腔內注射N-甲酰溶肉瘤素150毫克/公斤后,病变主要见于骨髓、胸腺、淋巴结、脾脏、小肠、大肠和睾丸。各种组织的病变发展过程不同,一般在给药后2—4天最为严重。在敏感的器官中,不同类型组织细胞对N-甲的敏感性有很大差別,最敏感的是睾丸的精原细胞和骨髓的嗜酸性粒细胞。 In this experiment, morphological methods were used to calculate the number of cells in the sections to compare the development of the lesions caused by N-formylcystein in various organs of mice and quantitatively measure the sensitivity of various cells to drugs. The results found that mice injected intraperitoneally with N-formylcitrosargin 150 mg / kg, the lesion found mainly in bone marrow, thymus, lymph nodes, spleen, small intestine, large intestine and testis. The development of various tissues of different lesions, usually 2-4 days after administration of the most serious. In sensitive organs, different types of tissue cells on the N-methyl sensitivity are very different, the most sensitive testicular spermatogonia and bone marrow eosinophils.