目的:分析阿奇霉素、左氧氟沙星在慢性支气管炎中的效果和安全性.方法:探究实验的对象是92例慢性支气管炎患者,实验对象符合探究实验的区间2020.10--2021.07我院收治的条件,按照对照实验的形式,将患者划分为实验组与对照组,分别应用阿奇霉素联合左氧氟沙星治疗措施和常规止咳化痰的治疗措施,记录患者治疗期间的相关数据,对比实验结果.结果:通过采取不同的治疗方式进行患者疾病的治疗,其中,实验组患者发热缓解时间为(2.13±0.52)天、咳痰缓解时间为(2.97±0.56)天、呼吸困难缓解时间为(3.42±“,”Objective:To analyze the effect and safety of azithromycin and levofloxacin in chronic bronchitis. Method:The subjects of the exploratory experiment were 92 patients with chronic bronchitis. The subjects met the conditions of the exploratory experiment from 2020.10 to 2021.07 in our hospital. According to the form of a controlled experiment, the patients were divided into experimental and control groups, and azithromycin was applied respectively. Combine levofloxacin treatment measures and conventional treatment measures for relieving cough and reducing phlegm, recording relevant data during treatment of patients, and comparing experimental results. Results:The patients were treated with different treatment methods. In the experimental group, the relief time of fever was (2.13±0.52) days, the relief time of expectoration was (2.97±0.56) days, the relief time of dyspnea was (3.42±0.76) days, and the relief time of cough was (4.03±1.46) days. Compared with the control group (2.89±0.64 days, 4.13±0.75 days, 5.10±0.85 days, 5.10±2.13 days), P＜0.05; The total effective rate of chronic bronchitis patients in experimental group (95.65％) was higher than that in control group (80.43％), P＜0.05; In terms of the safety of the treatment regimens in the two groups, the incidence rate of adverse reactions in patients with chronic bronchitis in the experimental group was 2.17％ lower than that in the control group (17.39％), and the safety of the treatment regimens in the experimental group was higher (P＜0.05).Conclusion:In the treatment of chronic bronchitis, the treatment of azithromycin combined with levofloxacin should be actively adopted, which can effectively improve the treatment effect of patients, and the safety of the treatment plan will be higher.