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为探讨淋球菌耐药谱与质粒谱之间的相互关系 ,对 1998年～ 1999年广东省湛江地区分离鉴定出的 98株淋球菌 ,以碱裂解法进行质粒的抽提 ,并分析质粒谱型的分布情况。结果显示 98株淋球菌流行株 ,检出质粒的有 90株 ,占91 84% ;质粒谱型 12种 ,以 7 4kb +4 2kb ,3 9 5kb +7 4kb +4 2kb为主 ,占3 8 76%。从而揭示湛江地区淋球菌流行株质粒的分布现状 ,为该地区淋病的分子流行病学研究打下了基础 ,但质粒谱与耐药性之间的关系尚有待进一步探讨。
To explore the relationship between drug resistance spectrum and plasmid spectrum of Neisseria gonorrhoeae, 98 strains of Neisseria gonorrhoeae isolated and identified in Zhanjiang, Guangdong Province from 1998 to 1999 were extracted by alkaline lysis method and the plasmid profiles The distribution of The results showed that 98 strains of Neisseria gonorrhoeae were found, 90 strains were detected, accounting for 91 84%. There were 12 plasmids with 7 4kb +4 2kb, 395kb +7 4kb +4 2kb, accounting for 38 76%. Thus revealing the present situation of the distribution of plasmids of Gonococcal strains in Zhanjiang, laying the foundation for the molecular epidemiological study of gonorrhea in this area. However, the relationship between plasmid spectrum and drug resistance remains to be further explored.