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本文对含碘造影剂,就其安全性、毒性、药理及应用作一综述,以达到合理使用的目的。一、发展情况碘造影剂的发展至目前为止经历了3个阶段。第一代造影剂由碘化油开始,于1928年swick 发明了用于泌尿系统造影的水溶性静脉碘造影剂——碘吡酮乙酸钠(Iopax 或Uroselectan)以及碘多啥(Neo opax 或Uroselectan-B)、碘吡拉啥(Iodopyracet)等,它们分别为单碘和双碘化合物,用于排泄性尿路造影,在当时提供了良好的显影效果,但有许多不良反应,特别是恶心、呕吐。碘司特是一
In this paper, Iodine-containing contrast agents, its safety, toxicity, pharmacology and applications for a review, in order to achieve the rational use of the purpose. First, the development of iodine contrast agent development so far has gone through three stages. The first generation of contrast agent started with iodized oil. In 1928 swick invented water-soluble intravenous contrast agents for urography - Iopax or Uroselectan and Neo opax or Uroselectan -B, Iodopyracet and the like, which are monoiodine and diiodide, respectively, for excretory urography, provided good development at the time but had many side effects, especially nausea, Vomit. Istolla is one