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目的 :探讨雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)和Her-2在乳腺癌空芯针穿刺(core needle biopsy,CNB)标本与手术切除标本的表达和符合率。方法:本研究为我院接受乳腺癌手术治疗、术前行CNB检测的病人,对配对的CNB和手术切除标本进行ER、PR和Her-2表达的检测,比较其结果和符合率。结果:136例乳腺癌病人ER、PR和Her-2的阳性率分别为78.7%、61.8%和22.1%,与手术切除标本的77.9%、64.7%和20.6%相比较,无统计学差异(P>0.05)。ER、PR和Her-2在CNB与手术切除标本的符合率分别为96.3%、86.8%和98.5%,κ值均>0.6(P<0.001)。3例CNB检测激素受体(hormonal receptor,HR)阴性的病人,在手术切除标本中均表达HR;2例手术切除标本HR阴性的病人,在CNB标本中有ER的表达。2例手术切除标本Her-2阴性的病人,在CNB标本表达Her-2。结论:ER、PR和Her-2表达在CNB和手术切除标本中具有较高的一致率,临床上可采用CNB进行乳腺癌相关受体指标的检测。
Objective: To investigate the expression of estrogen receptor (ER), progesterone receptor (PR) and Her-2 in breast cancer patients with core needle biopsy (CNB) and resected specimens and In line with the rate. Methods: This study was performed in our hospital for surgical treatment of breast cancer, preoperative CNB detection of patients with matched CNB and surgical specimens ER, PR and Her-2 expression were detected, the results and compliance rate. Results: The positive rates of ER, PR and Her-2 in 136 breast cancer patients were 78.7%, 61.8% and 22.1%, respectively, which were not significantly different from those of 77.9%, 64.7% and 20.6% of the resected specimens > 0.05). The coincidence rates of ER, PR and Her-2 in CNB and surgically resected specimens were 96.3%, 86.8% and 98.5%, respectively, with kappa values> 0.6 (P <0.001). Three patients with CNB negative for hormonal receptor (HR) expressed HR in all the resected specimens. Two patients with HR-negative specimens were found to have ER expression in CNB specimens. Her-2 was negative in 2 patients with surgical resection and Her-2 was expressed in CNB. CONCLUSIONS: The expression of ER, PR and Her-2 in CNB and resected specimens has a high concordance rate. Clinically, CNB can be used to detect the index of breast cancer related receptors.