论文部分内容阅读
本文初步研究了脑得安的药理作用．最大耐受量试验表明其LD50大于54g／kg；对醋酸致小白鼠扭体反应的影响结果表明，脑得安胶囊1．0g／kg和2．0g／kg（po）可显著减少小鼠的扭体次数；脑得安对二甲苯致小鼠耳廓炎症亦有显著抑制作用，脑得安2．0g／kg组的抑制作用与阿斯匹林（0．6g／kg，po）的作用效果相当．热板镇痛实验的结果显示，脑得安1．0g／kg和2．0g／kg（po）给药后30min，60min，120min均可显著提高小鼠的痛反应阈值．本实验结果表明脑得安具有明显的镇痛消炎作用．
This article initially studied the pharmacological effects of nadician. The maximum tolerated dose test showed that the LD50 was greater than 54 g/kg; the effect on the writhing response of mice induced by acetic acid showed that Naodean capsules 1.0 g/kg and 2.0 g/kg (po) significantly reduced the mice’s Writhing frequency; Naodedan also significantly inhibited auricle inflammation in mice induced by xylene, and the inhibitory effect of Nao Dean 2.0g/kg group and aspirin (0.6g/kg, po) The effect is quite. The results of hot plate analgesia experiments showed that the nausea of 1.0g/kg and 2.0g/kg (po) of the brain can significantly increase the pain response threshold in mice 30 minutes, 60 minutes, and 120 minutes after administration. The results of this experiment show that Naodecan has obvious analgesic and anti-inflammatory effects.