Puprose: It is a challenge to prevent irreversible amblyopia in infants suffering from Peters anomaly. In some cases of centrally located corneal opacifications an optical sector iridectomy can not lead to a clear optical axis. The homologous penetrating keratoplasty as early surgical procedure has shown an extremely poor outcome with a high risk of irreversible graft failure. We report on the autologous ipsilateral rotating penetrating keratoplasty in an eight- week- old infant suffering from Peters anomaly. Patients: An autologous ipsilateral rotating penetrating keratoplasty was performed in an eight- week- old infant suffering from Peters anomaly to prevent irreversible amblyopia. Results: After a follow- up time of 8 months we saw a clear graft within the optical axis without any complications in wound healing. We removed the single sutures two months after keratoplasty. Postoperative astigmatism could be corrected first by fitting a special nursery contact lens and after reduction of astigmatismbecause of suture removalwe fitted special nursery glasses. The intraocular pressure remained within the normal range during the follow- up period. Conclusion: The autologous ipsilateral rotating penetrating keratoplasty should be considered superior to homologous keratoplasty in infants withPeters anomaly if sector iridectomy is not advisable because of a central corneal opacification. Resulting high refractive errors can be successfully corrected by special contact lens fitting or by nursery glasses. Puprose: It is a challenge to prevent irreversible amblyopia in infants suffering from Peters anomaly. In some cases of centrally located corneal opacifications an optical sector iridectomy can not lead to a clear optical axis. The homologous penetrating keratoplasty as early surgical procedure has shown an extremely We report on the autologous ipsilateral flooding penetrating keratoplasty in an eight- week- old infant suffering from Peters anomaly. Patients: An autologous ipscute flooding penetrating keratoplasty was performed in an eight-week-old Results a After a follow-up time of 8 months we saw a clear graft within the optical axis without any complications in wound healing. We removed the single sutures two months after keratoplasty. Postoperative astigmatism could be corrected first by fitting a special nursery contact lens and after reductio n of astigmatismbecause of suture removal of fitted special nursery glasses. The autologous ipscute flooding penetrating keratoplasty should be considered superior to homologous keratoplasty in infants with Peters anomaly if sector iridectomy is not advisable because of a central corneal opacification. Resulting high refractive errors can be successfully corrected by special contact lens fitting or by nursery glasses.