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目的 探讨糖尿病肾病 型胶原水平的变化及给予葛根素治疗后的变化。方法 测定血清 型胶原与病程、糖基化血红蛋白、年龄、体质量指数的相关性 ;观察用葛根素前后的尿白蛋白、 型胶原及血液流变学变化。结果 糖尿病患者 型胶原水平明显升高 (P<0 .0 5 ) ,早期糖尿病肾病组较正常白蛋白尿组 型胶原水平明显升高 (P<0 .0 5 )。用葛根素治疗前后尿白蛋白降低。结论 葛根素对早期糖尿病肾病有治疗作用 ,其机制可能与抑制非酶糖基化反应及降低血液粘稠度有关。
Objective To investigate the changes of diabetic nephropathy collagen and the changes after the administration of puerarin. Methods The correlation of serum collagen, duration of disease, glycosylated hemoglobin, age and body mass index was measured. Urinary albumin, collagen and hemorrheology were observed before and after administration of puerarin. Results The level of diabetic collagen was significantly increased (P <0.05), and the level of collagen in early diabetic nephropathy group was significantly higher than that of normal albuminuria (P <0.05). Urinary albumin decreased with puerarin before and after treatment. Conclusion Puerarin has a therapeutic effect on early diabetic nephropathy, and its mechanism may be related to inhibition of nonenzymatic glycosylation and reduction of blood viscosity.