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目的:观察社区获得性肺炎患者(CAP)红细胞沉降率、血浆纤维蛋白原、C-反应蛋白水平变化,并探讨其临床意义。方法:选择诸暨市应店街镇中心卫生院于2013年8月-2014年6月收治的社区获得性肺炎患者70例作为研究对象,作为观察组,同期体检健康人员70例作为对照组,测定并比较治疗前、后两组红细胞沉降率、血浆纤维蛋白原、C-反应蛋白水平差异,并比较观察组重度CAP患者与非重度CAP患者三种检测指标水平差异,进一步探讨其临床意义。结果:70例社区获得性肺炎患者均治愈出院,观察组治疗前ESR、FIB、CRP水平分别为(39.7±9.9)mm/h、(6.9±1.1)g/L、(57.9±17.8)mg/L,均高于对照组,P<0.05。治愈出院时两组比较无明显差异,P>0.05.重度组治疗前ESR、FIB、CRP水平均高于非重度CAP患者,P<0.05,治愈后两组差异无统计学意义,P>0.05。结论:社区获得性肺炎患者红细胞沉降率、血浆纤维蛋白原、C-反应蛋白水平显著升高,且重度患者其升高愈显著,测定该三类指标有助于诊断及病情评估,具有重要临床价值。
Objective: To observe the changes of erythrocyte sedimentation rate, plasma fibrinogen and C-reactive protein in patients with community-acquired pneumonia (CAP) and to explore its clinical significance. Methods: Seventy patients with community-acquired pneumonia who were treated in Zhendian Town Center Hospital of Zhuji City from August 2013 to June 2014 were selected as the research object. As the observation group, 70 healthy people in the same period were selected as the control group, The erythrocyte sedimentation rate, plasma fibrinogen and C-reactive protein in the two groups before and after treatment were compared. The differences of the three test indexes between the severe CAP patients and the non-severe CAP patients in the observation group were compared, and the clinical significance was further explored. RESULTS: Seventy patients with community-acquired pneumonia were cured and discharged. The levels of ESR, FIB and CRP in the observation group before treatment were (39.7 ± 9.9) mm / h, (6.9 ± 1.1) g / L and (57.9 ± 17.8) mg / L, both higher than the control group, P <0.05. There was no significant difference between the two groups when cured, P> 0.05. The levels of ESR, FIB and CRP in severe group were higher than those in non-severe CAP group (P <0.05). There was no significant difference between the two groups after treatment (P> 0.05). Conclusion: The erythrocyte sedimentation rate, plasma fibrinogen and C-reactive protein were significantly increased in patients with community-acquired pneumonia, and more significant in patients with severe pneumonia. The determination of these three indexes is helpful for the diagnosis and assessment of disease, and has important clinical value.