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目的与方法:为了解p16基因与胆囊癌发生、生物学行为和预后的关系,采用免疫组化ABC法对36例胆囊癌和20例胆囊腺瘤中的p16蛋白进行了检测.结果:胆囊癌中p16蛋白的阳性率低于胆囊腺瘤(P<0.05);不同组织类型和分化程度不同的胆囊癌之间p16蛋白的阳性率无明显差别(P>0.05);p16蛋白的表达与胆囊癌有无浸润和淋巴结转移及病人的生存期密切相关(P<0.05).结论:p16基因失活与胆囊癌的发生有关,p16蛋白表达缺失与胆囊癌进展和预后不良有关.
Aims and methods: To understand the relationship between p16 gene and gallbladder carcinogenesis, biological behavior and prognosis, we used immunohistochemical ABC method to detect p16 protein in 36 cases of gallbladder carcinoma and 20 cases of gallbladder adenoma. Results: Gallbladder carcinoma The positive rate of p16 protein was lower than that of gallbladder adenoma (P<0.05). There was no significant difference in the positive rate of p16 protein between gallbladder carcinomas with different tissue types and different degrees of differentiation (P>0.05); p16 protein expression and gallbladder carcinoma There was a close relationship between invasiveness and lymph node metastasis and patient survival (P<0.05). Conclusion: The inactivation of p16 gene is associated with the occurrence of gallbladder carcinoma. The loss of p16 protein expression is associated with the progression of gallbladder carcinoma and poor prognosis.