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目的 :探讨中药制剂红要子烧伤酊的毒理作用 ,评价其临床效果及应用前景。方法 :烧伤面积 1%～2 0 %Ⅱ度伤为主的烧伤患者 40例 ,外用烧伤酊与磺胺嘧啶银 (SD Ag)作对照 ,观察用药反应 ,愈合时间。同时选择豚鼠及家兔分别进行烧伤酊的皮肤急性毒性试验 ,皮肤长期毒性试验 ,皮肤刺激试验及皮肤过敏试验。结果 :烧伤酊组与SD Ag组治疗Ⅱ度烧伤有效率均达 10 0 %。在创面反应、愈合时间上统计学处理差异无显著性 (P >0 0 5 )。毒理实验结果表明烧伤酊对皮肤仅有轻微的刺激反应及过敏反应。结论 :红要子烧伤酊是一种副作用小、使用安全可靠的中药类烧伤创面外用药 ,值得进一步推广应用。
Objective: To explore the toxicological effects of traditional Chinese medicine preparations of red sap tincture and to evaluate its clinical effects and application prospects. Methods: Forty burn patients were divided into 1% ~ 20% burn wounds with Ⅱ degree wounds. Topical burns tincture was treated with SD Ag, and the reaction and healing time were observed. At the same time, guinea pigs and rabbits were selected respectively for acute dermal toxicity test of burn tincture, long-term skin toxicity test, skin irritation test and skin allergy test. Results: The burn burn tincture group and SD Ag group Ⅱ degree burn rate reached 100%. There was no significant difference in the time of wound healing and healing (P> 0.05). Toxicology results show that burn tincture on the skin only mild irritation and allergic reactions. Conclusion: The red tincture burn is a kind of small side effects, the use of safe and reliable traditional Chinese medicine burn wounds, it is worth further promotion and application.