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目的:分析北京市西城区急性呼吸道感染病原谱及流行特征，为呼吸道传染病防治策略的制定提供科学依据。方法:应用荧光PCR法，对2018年北京市西城区3家哨点医院就诊的急性呼吸道感染病例呼吸道标本进行多种病原体检测。结果:803例样本中，呼吸道感染总阳性率为28.27%（227/803）。肺炎病例和门诊病例中，下呼吸道标本的阳性率均高于上呼吸道标本（n x2=7.332，n P=0.007；n x2=13.698，n P<0.01）。病原体感染前5位依次为流感病毒、副流感病毒、鼻病毒、肠道病毒和支原体。急性呼吸道感染高峰主要集中在3月、8月和12月，不同病原体的季节特征各不相同。14岁及以下儿童副流感病毒感染阳性率较高（n x2=12.411，n P<0.01）；14岁以上人群流感病毒和支原体感染阳性率较高（n x2=10.306，n P=0.001；n x2=6.470，n P=0.011）。n 结论:流感病毒、副流感病毒、鼻病毒、肠道病毒和支原体为北京市西城区急性呼吸道感染的主要病原体，不同病原体有各自的季节特征，且不同年龄组病原谱不同。“,”Objective:To analyze the pathogen spectrum and epidemiological characteristics of acute respiratory infections in Xicheng district of Beijing, so as to provide scientific evidences for the development of prevention and treatment of respiratory infectious diseases.Methods:In 2018, respiratory tract specimens of acute respiratory infections from 3 sentinel hospitals in Xicheng district were collected, and multiple pathogens were detected with RT-PCR method.Results:Among the 803 samples, the overall positive rate of respiratory infections was 28.27% (227/803). The positive rates of lower respiratory tract specimens in pneumonia cases and outpatient cases were both higher than that of upper respiratory tract specimens (n x2=7.332, n P=0.07; n x2=13.698, n P< 0.01). The top five pathogens were influenza virus, parainfluenza virus, rhinovirus, enterovirus and mycoplasma. The peaks of acute respiratory infections were mainly in March, August and December. The seasonal characteristics of various pathogens were different. The positive rate of parainfluenza vrius was higher in the 0-14 years old group (n x2=12.411, n P<0.001). The positive rates of influenza virus and mycoplasma were higher in people over 14 years old (n x2=10.306, n P<0.001;n x2=6.470, n P<0.011).n Conclusions:Influenza virus, parainfluenza virus, rhinovirus, enterovirus and mycoplasma were the main pathogens of acute respiratory infections in Xicheng district of Beijing. The pathogens showed different seasonal characteristics, and the pathogen spectrums were different among various age groups.